Description

Epithelial cell adhesion molecule (EPCAM). May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.


Clinical trials

NCT03013712 - Colon Cancer, Esophagus Cancer, Hepatic Carcinoma, Pancreatic Cancer, Prostate Cancer
NCT02729493 - Liver Neoplasms
NCT02725125 - Stomach Neoplasms


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene EPCAM.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present.