Epithelial cell adhesion molecule (EPCAM). May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
NCT03013712 -
Colon Cancer, Esophagus Cancer, Hepatic Carcinoma, Pancreatic Cancer,
Prostate Cancer
NCT02729493 -
Liver Neoplasms
NCT02725125 -
Stomach Neoplasms
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present.